Knoxville is 889 feet above sea level.

Knoxville is situated in the Great Appalachian Valley (known locally as the Tennessee Valley).

Snowfall in Knoxville averages approximately 6.4 inches annually.

According to the United States Census Bureau, the city of Knoxville has a total area of 104.2 square miles.

Sharp's Ridge in North Knoxville has an elevation of 1,391 feet.

House Mountain, the highest point in Knox County, has an elevation of 2,064 feet.

The Tennessee River that passes through Knoxville is part of Fort Loudoun Lake.

The Tennessee Valley is part of a subrange of the Appalachian Mountains known as the Ridge-and-Valley Appalachians.

Elevations range from just over 800 feet (240 m) along the riverfront to just over 1,000 feet (300 m) on various hilltops in West Knoxville.

Knoxville falls in the humid subtropical climate zone.

Annual precipitation averages around 48 inches.

Knoxville is within a day's driving distance from two-thirds of the population of the U.S. east of the Mississippi River.

Knoxville is the central city in the Knoxville Metropolitan Area that covers Knox, Anderson, Blount, Loudon, and Union counties.

The Knoxville Metropolitan area includes unincorporated communities such as Halls Crossroads, Powell, Karns, Corryton, Concord, and Mascot, which are located in Knox County outside of Knoxville's city limits.

Along with Knoxville, major municipalities in the Knoxville Metropolitan Area include Alcoa, Maryville, Lenoir City, Loudon, Farragut, Oak Ridge, Clinton, and Maynardville.

As of 2016, the population of the Knoxville Metropolitan Area was 868,546.

Knoxville's two tallest buildings are the 27-story First Tennessee Plaza and the 24-story Riverview Tower, both on Gay Street.